Clinical Evaluation of the Effect of Methylprednisolone Sodium Succinate and Meloxicam in Experimental Acute Spinal Cord Injury

Background: Central nervous system (CNS) has limited repair capacity, and any spinal cord injury (SCI) can cause persistent disability in motor, sensory, autonomic functions. The harmful reactions around the lesion must be stopped to prevent this consequence. Objectives: present study compares clinical effects of methylprednisolone sodium succinate (MPSS) meloxicam acute an animal model rats. Methods: We randomly divided 24 male Wistar rats into 4 groups: 1) sham, 2) placebo, 3) SCI+MPSS (30 mg/kg, IV), 4) SCI+meloxicam (1 SC). used a Fogarty embolectomy catheter induce compression rats’ T8-T9 segment. drugs were injected one hour after surgery. Neurological evaluation was performed using BBB (Basso, Beattie, Bresnahan) test immediately recovery then once week for up 6 weeks. Results: According results, single-dose administration MPSS improved motor function significantly compared placebo. But, there no significant difference between groups placebo (P>0.01). Conclusion: In evaluation, meloxicam.